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Photodynamic therapy and fluorescent diagnostics of head and neck cancer with second-generation photosensitizers
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Paper Abstract

Photodynamic Therapy (PDT) and fluorescent diagnostics (FD) using Photosense was provided in 50 patients with head and neck cancer T1-3 stage, in 89 patients with skin cancer, using Radaclorine (RC) in 42 patients with T1-4 stage basal cell carcinoma (BCC),in 6 patients with oral cancer. Detection of borders of tumor, intensity of accumulation of photosensitizers in tumor, normal tissues were done by Spectral-fluorescent Complex. We've got fluorescence of a11 tumors and additional fluorescence zones were found with cytological verification. We used semiconductive lasers: Milon - λ = 660+2nm, light dose 200 - 300 J/cm2 and Biospec (λ=672+2nm), multiple laser surface and interstitial irradiation with total light dose till 400-600 J/cm2. After PDT with PS in head and neck cancer we've had complete response (CR) in 66.0% and partial response (PR) in 30.0%, with RC CR in BCC T1-2NOMO - 92.9%, in recurrencies CR - 60,6%, PR - 39,4%. The efficacy of PDT with PS was higher (CR - 86.7%, PR - 13,3%) and the recurrence rate in 6 months lower. Our experience show pronounced efficacy of PDT for head and neck tumors of different localization and histology, FD is providing diagnostically significant information, demonstrated high sensitivity and specificity.

Paper Details

Date Published: 7 December 2006
PDF: 6 pages
Proc. SPIE 5973, Current Research on Laser Use in Oncology: 2000-2004, 597308 (7 December 2006); doi: 10.1117/12.640039
Show Author Affiliations
Elena G. Vakulovskaya, N.N. Blokhin Russian Cancer Research Ctr., RAMS (Russia)

Published in SPIE Proceedings Vol. 5973:
Current Research on Laser Use in Oncology: 2000-2004
Andrei V. Ivanov; Mishik A. Kazaryan, Editor(s)

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