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Proceedings Paper

The relativity between cytokines and psoriasis and the influence on its variation induced by ILLLI
Author(s): Jing Zhu; Fan Nie; Xiawen Yuan; Meijue Zhang
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Paper Abstract

Objective: To explore the relativity between cytokines such as IL-8, TNF-α, VEGF and psoriasis and the influence on its variation by ILLLI. Methods: 47 patients with psoriasis were divided into 5 groups, treated with ILLLI (1h per day, a course of treatment is 10 days), observed the variation of IL-8, TNF-α and VEGF in peripheral blood of patients with psoriasis between pre and post treatment and compared with the control. Results: 1. In each case of psoriasis, the concentration of IL-8 in blood was significantly higher than that of control group. After treatment, the concentrations of A group, B group and C group were decreased significantly, which were close to the control. The related statistical analysis showed significant difference. Among them, A group decreased most significantly; Although there is no significant difference in concentration of IL-8 of D group and E group between pre and post treatment, the trend of them became to keep decreasing. In each case of psoriasis, the concentration of TNF-α in blood was much lower than that of control group. The concentration of TNF-α in A, C, D group increased significantly as compared with pre-irradiation except that in E group. In cases, the concentrations of VEGF in blood were much higher than that of control group. In each group, there was no difference in VEGF concentration between pre and post irradiation. Conclusions: The decrease of IL-8 induced by ILLLI might be related with its immunosuppressive function. It suppressed the activity of CD4+T cell which could secrete a great deal of IL-8 and play an important role to the tache of psoriasis onset. So in the psoriasis patients who were treated with ILLLI, the production of TNF-α could be suppressed. In patients, the increasing of VEGF might be related with the increasing of IL-8. There was no difference of it between pre and post ILLLI treatment might because VEGF was not the action target of ILLLI.

Paper Details

Date Published: 11 September 2006
PDF: 8 pages
Proc. SPIE 5967, 2004 Shanghai International Conference on Laser Medicine and Surgery, 59671G (11 September 2006); doi: 10.1117/12.639323
Show Author Affiliations
Jing Zhu, Renji Hospital/Shanghai Second Medical Univ. (China)
Fan Nie, Renji Hospital/Shanghai Second Medical Univ. (China)
Xiawen Yuan, Renji Hospital/Shanghai Second Medical Univ. (China)
Meijue Zhang, Renji Hospital/Shanghai Second Medical Univ. (China)


Published in SPIE Proceedings Vol. 5967:
2004 Shanghai International Conference on Laser Medicine and Surgery
Jing Zhu, Editor(s)

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