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Proceedings Paper

Influence of intravascular low level He-Ne laser irradiation on iNOS, total-NOS, and ET-1 in acute spinal cord-injured rabbits
Author(s): Zhenchun Yin; Yinghai Dong; Jing Zhu
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Paper Abstract

Objective To research the influence of intravascular low level Laser irradiation (ILLLI) on total NOS, iNOS, and ET-1 in spinal cord following acute spinal cord injury (ASCI), and discuss the protective effects of ILLLI on neurons. Methods 72 rabbits were randomly divided into 3 groups: treatment group, injury group and control group. In treatment group and injury group, after laminectomy at the level of T-13, ASCI was performed by using Allen's method with slight modification (6g×10cm) on rabbits. After injury, rabbits were treated immediately with He-Ne laser (power 5 mW, 1 hour per day for 10 days). At the day of 10th after treatment, total-NOS, iNOS, and ET-1 in spinal cord tissues were measured. Results The expression level of total-NOS, iNOS, and ET-1 in spinal cord in injury group were significantly higher than those in control group (P<0.05), while after ILLLI the level of these index in treatment group decreased statistically significantly compared with those in injury group (P<0.05). Conclusion ILLLI can significantly decrease the expression level of total-NOS, iNOS, and ET-1 in spinal cord. It indicates that ILLLI can relieve the overexpression of total-NOS, iNOS, and ET-1, and thus can perform protective effects on neurons in the course of secondary spinal cord injury (SSCI) following ASCI

Paper Details

Date Published: 11 September 2006
PDF: 5 pages
Proc. SPIE 5967, 2004 Shanghai International Conference on Laser Medicine and Surgery, 59671D (11 September 2006); doi: 10.1117/12.639315
Show Author Affiliations
Zhenchun Yin, Renji Hospital/ShangHai Second Medical Univ. (China)
Yinghai Dong, Renji Hospital/ShangHai Second Medical Univ. (China)
Jing Zhu, Shanghai Medical Ctr. for Laser Research (China)


Published in SPIE Proceedings Vol. 5967:
2004 Shanghai International Conference on Laser Medicine and Surgery
Jing Zhu, Editor(s)

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