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Proceedings Paper

The metabolization of ALA taken orally and its effect on skin and tumors
Author(s): Jing Zhu; Hui-Guo Zhang; Mei-Jue Zhang; Xiaoqing Bao; Min Yan; Liping Lu
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Paper Abstract

Objective: Research on the metabolize of ALA (after take orally) on skin and tumor, to find the best dose and diagnostic time of ALA after take orally Methods: Measure the fluorescence spectra of tumor and skin with different dose of ALA take orally (20mg/kg, 40mg/kg, 60mg/kg, 80mg/kg, 100mg/kg) and different time after ALA take orally (1h, 2h, 4h, 6h, 8h, 10h, 12h, 24h, 48h) when irradiated by laser. By analyzing the spectrum of fluorescence with optical multi-channel analyzer (OMA), also the fluorescence intensity should be normalized. Result: The best ratio (Itumor/Inomal) of skin was obtained at 60mg/kg, of ALA take orally and 6-8h after ALA take orally Conclusion: Measure the fluorescence spectrum of tumor and skin by using optical multi-channel analyzer (OMA). The best dose was 60mg/kg of ALA take orally and the measure time was 6-8 hours after ALA taking orally.

Paper Details

Date Published: 11 September 2006
PDF: 6 pages
Proc. SPIE 5967, 2004 Shanghai International Conference on Laser Medicine and Surgery, 596712 (11 September 2006); doi: 10.1117/12.639240
Show Author Affiliations
Jing Zhu, Renji Hospital/Shanghai No. 2 Medical Univ. (China)
Hui-Guo Zhang, Renji Hospital/Shanghai No. 2 Medical Univ. (China)
Mei-Jue Zhang, Renji Hospital/Shanghai No. 2 Medical Univ. (China)
Xiaoqing Bao, Renji Hospital/Shanghai No. 2 Medical Univ. (China)
Min Yan, Renji Hospital/Shanghai No. 2 Medical Univ. (China)
Liping Lu, Renji Hospital/Shanghai No. 2 Medical Univ. (China)


Published in SPIE Proceedings Vol. 5967:
2004 Shanghai International Conference on Laser Medicine and Surgery
Jing Zhu, Editor(s)

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