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Proceedings Paper

Photodynamic therapy on the ultrastructure of glioma cell
Author(s): Shaoshan Hu; Ruyou Zhang; Yongri Zheng
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Paper Abstract

OBJECTIVE: the main purpose of this experiment was to study the change of C6 glioma cells' ultrastructure treated by photodynamic therapy (PDT), observe the change of morphology METHOD: Make the model of rat glioma by transplanted C6 glioma cells into caudate nucleus, treated the glioma rat by PDT after two weeks. Observed the difference of subcellular structure before and after PDT by electron microscope. RESULT: Apoptosis and necrosis can be seen after treated by PDT in the C6 glioma, basal membrance damaged, number of cellular organ of endothelial cell of blood capillary declined, tight junction of endothelial cell lengthen and the gap enlarge. The PDT has slightly effect on the nomorl rat's subcellular structue. CONCLUSION: PDT can induce the apoptosis and necrosis of C6 glioma cell. The damage of the ultramicrostructure of mitochondria and endoplasmic reticulum was the foundmentol of the change. PDT initiate the damage of BBB of the C6 glioma cell and weeken the function, and makes it a useful way of treating the glioma combined with chemotherapy.

Paper Details

Date Published: 11 September 2006
PDF: 6 pages
Proc. SPIE 5967, 2004 Shanghai International Conference on Laser Medicine and Surgery, 59670Y (11 September 2006); doi: 10.1117/12.639223
Show Author Affiliations
Shaoshan Hu, Harbin Medical Univ. (China)
Ruyou Zhang, Harbin Medical Univ. (China)
Yongri Zheng, Harbin Medical Univ. (China)

Published in SPIE Proceedings Vol. 5967:
2004 Shanghai International Conference on Laser Medicine and Surgery
Jing Zhu, Editor(s)

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