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Proceedings Paper

Applications of dynamic light scattering, fluorescence microscopy and fluorescence spectroscopy in DB-67 liposomal formulation studies
Author(s): Stefan Kruszewski; Blanka Ziomkowska; Michał Cyrankiewicz; Lori Latus; David Bom
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Paper Abstract

Campthothecin (CPT) and its analogues as prominent anticancer agents are currently the subject of the intensive studies. One of the most promising camptothecin analogues is 7-tert-butyldimethylsil- 1 0-hydroxycampthothecin called DB-67. It is characterized by high affinity to SUV (small unilamellar lipids vesicles) and relatively high stability in human blood. The studies of liposomal formulation as a delivery systems for DB-67 are the subject of this paper. The methods of dynamic light scattering (DLS), fluorescence microscopy (FM) and fluorescence spectroscopy (FS) are used to determine the physical properties of DB-67 liposomal formulation.

Paper Details

Date Published: 6 December 2006
PDF: 5 pages
Proc. SPIE 5945, 14th Slovak-Czech-Polish Optical Conference on Wave and Quantum Aspects of Contemporary Optics, 59451M (6 December 2006); doi: 10.1117/12.639044
Show Author Affiliations
Stefan Kruszewski, Ludwik Rydygier Medical Univ. in Bydgoszcz (Poland)
Blanka Ziomkowska, Ludwik Rydygier Medical Univ. in Bydgoszcz (Poland)
Michał Cyrankiewicz, Ludwik Rydygier Medical Univ. in Bydgoszcz (Poland)
Lori Latus, Tigen Pharmaceuticals, Inc. (United States)
David Bom, Athersys, Inc. (United States)


Published in SPIE Proceedings Vol. 5945:
14th Slovak-Czech-Polish Optical Conference on Wave and Quantum Aspects of Contemporary Optics
Anton Štrba; Dagmar Senderákova; Miroslav Hrabovský, Editor(s)

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