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Proceedings Paper

Organic light emitting diodes and photodetectors: Toward applications in lab-on-a-chip portable devices
Author(s): Xuhua Wang; Oliver Hofmann; Jingsong Huang; Edward M. Barrett; Rupa Das; Andrew J. de Mello; John C. de Mello; Donal D. C. Bradley
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Paper Abstract

We report that polymer light emitting diodes (pLEDs) and polymer photodetectors can be integrated on disposable polydimethylsiloxane [PDMS] microfluidic flowcells to form hybrid microchips for bioluminescence applications. PLEDs were successfully employed as excitation light sources for microchip based fluorescence detection of microalbuminuria (MAU), an increased urinary albumin excretion indicative of renal disease. To circumvent the use of optical filters, fluorescence was detected perpendicular to the biolabel flow direction using a CCD spectrophotometer. Prior to investigating the suitability of polymer photodiodes as integrated detectors for fluorescence detection, their sensitivity was tested with on-chip chemiluminescence. The polymer photodetector was integrated with a PDMS microfluidic flowcell to monitor peroxyoxalate based chemiluminescence (CL) reactions on the chip. This work demonstrates that our polymer photodetectors exhibit sensitivities comparable to inorganic photodiodes. Here we prove the concept that thin film solution-processed polymer light sources and photodetectors can be integrated with PDMS microfluidic channel structures to form a hybrid microchip enabling the development of disposable low-cost diagnostic devices for point-of-care analysis.

Paper Details

Date Published: 19 January 2006
PDF: 9 pages
Proc. SPIE 6036, BioMEMS and Nanotechnology II, 60361O (19 January 2006); doi: 10.1117/12.638252
Show Author Affiliations
Xuhua Wang, Imperial College London (United Kingdom)
Oliver Hofmann, Imperial College London (United Kingdom)
Jingsong Huang, Imperial College London (United Kingdom)
Edward M. Barrett, Imperial College London (United Kingdom)
Rupa Das, Imperial College London (United Kingdom)
Andrew J. de Mello, Imperial College London (United Kingdom)
John C. de Mello, Imperial College London (United Kingdom)
Donal D. C. Bradley, Imperial College London (United Kingdom)

Published in SPIE Proceedings Vol. 6036:
BioMEMS and Nanotechnology II
Dan V. Nicolau, Editor(s)

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