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Proceedings Paper

Preliminary investigations in vitro optical clearing of rat skin using island damage method for accelerated delivery of index-matching agents
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Paper Abstract

Strong light scattering in skin prevents precise targeting of optical energy in therapeutic and diagnostic applications. Optical immersion based on matching refractive mdcx of scattering centers with that of surrounding matter through introduction of an exogenous index-matching agent can alleviate the problem. However, slow diffusion of the index-matching agent through skin barrier makes practical implementation of this approach difficult. We propose a method of accelerating penetration of the index-matching compounds by enhancing skin permeability through creating a lattice of micro-zones (islets) of limited thermal damage in the stratum comeum. Two index-matching agents, glucose and glycerol, were tested. Glycerol used as index-matching agent gave noticeably better clearance then 40% glucose solution.

Paper Details

Date Published: 22 June 2005
PDF: 5 pages
Proc. SPIE 5771, Saratov Fall Meeting 2004: Optical Technologies in Biophysics and Medicine VI, (22 June 2005); doi: 10.1117/12.634858
Show Author Affiliations
A. A. Gavrilova, Saratov State Univ. (Russia)
D. Tabatadze, Palomar Medical Technologies Inc. (United States)
J. Childs, Palomar Medical Technologies Inc. (United States)
I. Yaroslavsky, Palomar Medical Technologies Inc. (United States)
G. Altshuler, Palomar Medical Technologies Inc. (United States)
A. B. Pravdin, Saratov State Univ. (Russia)
V. V. Tuchin, Saratov State Univ. (Russia)


Published in SPIE Proceedings Vol. 5771:
Saratov Fall Meeting 2004: Optical Technologies in Biophysics and Medicine VI
Valery V. Tuchin, Editor(s)

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