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Proceedings Paper

Optical methods in modeling nicotine effect on the surface water of cell membranes
Author(s): Tatyana V. Alexandrova; Svetlana M. Rogacheva; Pavel E. Kuznetsov; Tamara I. Gubina
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Paper Abstract

Fluorescence and spectrophotometric methods have been used for investigation of nicotine action on the state and mobility of the surface water. The surfaces of membranes and proteins were simulated with the help of liposomes and ultradispersive diamonds consequently. Nicotine was shown to reduce the stability of liposomes and to change the aggregative ability of ultradispersive diamonds. The wave-like curves for the nicotine concentration dependences of the pointed features were observed. Such shape of responses was suggested to be due to the changing in structure and dynamics of water hydrogen bonds net near the surface of the model systems induced by nicotine molecules. The surface water phase was supposed to be one of signal elements ofthe ligand receptor recognition process.

Paper Details

Date Published: 22 June 2005
PDF: 7 pages
Proc. SPIE 5771, Saratov Fall Meeting 2004: Optical Technologies in Biophysics and Medicine VI, (22 June 2005); doi: 10.1117/12.634831
Show Author Affiliations
Tatyana V. Alexandrova, Saratov State Technical Univ. (Russia)
Svetlana M. Rogacheva, Saratov Military Institute of Radioactive, Chemical and Biological Defense (Russia)
Pavel E. Kuznetsov, Saratov State Univ. (Russia)
Tamara I. Gubina, Saratov State Technical Univ. (Russia)


Published in SPIE Proceedings Vol. 5771:
Saratov Fall Meeting 2004: Optical Technologies in Biophysics and Medicine VI
Valery V. Tuchin, Editor(s)

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