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Proceedings Paper

Extraction of tissue optical properties from optical coherence tomography images for diagnostic purposes
Author(s): Lars Thrane; Michael H. Frosz; David Levitz; Thomas M. Jorgensen; Claus B. Andersen; Peter R. Hansen; Jurga Valanciunaite; Johannes Swartling; Stefan Andersson-Engels; Andreas Tycho; Harold T. Yura; Peter E. Andersen
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Paper Abstract

The concept of optical coherence tomography (OCT) for high-resolution imaging of tissues in vivo is introduced. Analytical and numerical models for describing and understanding the light propagation in samples imaged by OCT systems are presented. An analytical model for calculating the OCT signal based on the extended Huygens-Fresnel principle and valid both for single and multiple scattering regimes is outlined. From this model, an algorithm for extracting tissue optical properties for multi-layered tissues is derived. The algorithm is first verified for various optical properties and geometries using solid phantoms and numerical simulations. The applicability of the algorithm for extraction of tissue optical properties is then demonstrated for vascular tissue samples ex vivo. With the use of data from numerical phantoms, the validity of the OCT extraction algorithm for a two-layer geometry is further supported. It is concluded that by using optical properties extracted from OCT images of human tissues, the clinical utility of OCT imaging can be substantially increased.

Paper Details

Date Published: 22 June 2005
PDF: 12 pages
Proc. SPIE 5771, Saratov Fall Meeting 2004: Optical Technologies in Biophysics and Medicine VI, (22 June 2005); doi: 10.1117/12.634767
Show Author Affiliations
Lars Thrane, Riso National Lab. (Denmark)
Michael H. Frosz, Riso National Lab. (Denmark)
COM, Technical Univ. of Denmark (Denmark)
David Levitz, Riso National Lab. (Denmark)
Lund Institute of Technology (Sweden)
Thomas M. Jorgensen, Riso National Lab. (Denmark)
Claus B. Andersen, Rigshospitalet (Denmark)
Peter R. Hansen, Amtssygehuset i Gentofte (Denmark)
Jurga Valanciunaite, Lund Institute of Technology (Sweden)
Johannes Swartling, Lund Institute of Technology (Sweden)
Stefan Andersson-Engels, Lund Institute of Technology (Sweden)
Andreas Tycho, OCT Innovation ApS (Denmark)
Harold T. Yura, The Aerospace Corp. (United States)
Peter E. Andersen, Riso National Lab. (Denmark)

Published in SPIE Proceedings Vol. 5771:
Saratov Fall Meeting 2004: Optical Technologies in Biophysics and Medicine VI
Valery V. Tuchin, Editor(s)

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