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Proceedings Paper

A multi-projection non-contact tomography setup for imaging arbitrary geometries
Author(s): Heiko Meyer; Anikitos Garofalakis; Giannis Zacharakis; Eleftherios N. Economou; Clio Mamalaki; Sifis Papamatheakis; Vasilis Ntziachristos; Jorge Ripoll
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Paper Abstract

Optical imaging and tomography in tissues can facilitate the quantitative study of several important chromophores and fluorophores in-vivo. Due to this fact, there has been great interest in developing imaging systems offering quantitative information on the location and concentration of chromophores and fluorescent probes. However, most imaging systems currently used in reasearch make use of fiber technology for delivery and detection, which restricts the size ofthe photon collecting arrays leading to insufficient spatial sampling and field of view. To enable large data sets and full 3600angular measurements, we developed a novel imaging system that enables 3D imaging of fluorescent signals in bodies of arbitrary shapes in a non-contact geometry in combination with a 3D surface reconstruction algorithm. The system is appropriate for in-vivo small animal imaging of fluorescent probes. The system consists of a rotating sample holder and a lens coupled CCD camera in combination with a fiber coupled scanning device. The accuracy of the system in obtaining the surface reconstruction was measured to be in the order of 1μm.

Paper Details

Date Published: 22 June 2005
PDF: 8 pages
Proc. SPIE 5771, Saratov Fall Meeting 2004: Optical Technologies in Biophysics and Medicine VI, (22 June 2005); doi: 10.1117/12.634623
Show Author Affiliations
Heiko Meyer, Foundation for Research and Technology Hellas (Greece)
Anikitos Garofalakis, Foundation for Research and Technology Hellas (Greece)
Giannis Zacharakis, Foundation for Research and Technology Hellas (Greece)
Eleftherios N. Economou, Foundation for Research and Technology Hellas (Greece)
Clio Mamalaki, Foundation for Research and Technology Hellas (Greece)
Sifis Papamatheakis, Foundation for Research and Technology Hellas (Greece)
Vasilis Ntziachristos, Massachusetts General Hospital, Harvard Medical School (United States)
Jorge Ripoll, Foundation for Research and Technology Hellas (Greece)


Published in SPIE Proceedings Vol. 5771:
Saratov Fall Meeting 2004: Optical Technologies in Biophysics and Medicine VI
Valery V. Tuchin, Editor(s)

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