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Proceedings Paper

Investigation of human biomarkers in exhaled breath by laser photoacoustic spectroscopy
Author(s): D. C. Dumitras; G. Giubileo; A. Puiu
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Paper Abstract

The paper underlines the importance of breath tests in medicine and the potential of laser techniques to measure in-vivo and in real time human biomarkers. The presence of trace amounts of gases or the metabolites of a precursor in exhaled air could be linked to kidney or liver malfunction, asthma, diabetes, cancer, ulcers or neurological disorders. The measurement of some human biomarkers (ethylene, ammonia), based on laser photoacoustic spectroscopy methods, insure very high sensitivity and selectivity. The technical characteristics of this instrument were measured to determine the detection limits (sub-ppb for ethylene). The results of ethylene release following lipid peroxidation initiated by X-ray irradiation or ingestion of radioactive compounds are presented. The possibility to extend this technique for measurement of breath ammonia levels in patients with end-stage renal disease while they are undergoing hemodialysis is discussed.

Paper Details

Date Published: 7 June 2005
PDF: 11 pages
Proc. SPIE 5850, Advanced Laser Technologies 2004, (7 June 2005); doi: 10.1117/12.633696
Show Author Affiliations
D. C. Dumitras, National Institute for Laser, Plasma and Radiation Physics (Romania)
G. Giubileo, ENEA (Italy)
A. Puiu, National Institute for Laser, Plasma and Radiation Physics (Romania)


Published in SPIE Proceedings Vol. 5850:
Advanced Laser Technologies 2004
Ivan A. Shcherbakov; Anna Giardini; Vitali I. Konov; Vladimir I. Pustovoy, Editor(s)

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