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Proceedings Paper

Ten-minute analysis of drugs and metabolites in saliva by surface-enhanced Raman spectroscopy
Author(s): Chetan Shende; Frank Inscore; Paul Maksymiuk; Stuart Farquharson
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Paper Abstract

Rapid analysis of drugs in emergency room overdose patients is critical to selecting appropriate medical care. Saliva analysis has long been considered an attractive alternative to blood plasma analysis for this application. However, current clinical laboratory analysis methods involve extensive sample extraction followed by gas chromatography and mass spectrometry, and typically require as much as one hour to perform. In an effort to overcome this limitation we have been investigating metal-doped sol-gels to both separate drugs and their metabolites from saliva and generate surface-enhanced Raman spectra. We have incorporated the sol-gel in a disposable lab-on-a-chip format, and generally no more than a drop of sample is required. The detailed molecular vibrational information allows chemical identification, while the increase in Raman scattering by six orders of magnitude or more allows detection of microg/mL concentrations. Measurements of cocaine, its metabolite benzoylecgonine, and several barbiturates are presented.

Paper Details

Date Published: 11 November 2005
PDF: 7 pages
Proc. SPIE 6007, Smart Medical and Biomedical Sensor Technology III, 60070S (11 November 2005); doi: 10.1117/12.633281
Show Author Affiliations
Chetan Shende, Real-Time Analyzers, Inc. (United States)
Frank Inscore, Real-Time Analyzers, Inc. (United States)
Paul Maksymiuk, Real-Time Analyzers, Inc. (United States)
Stuart Farquharson, Real-Time Analyzers, Inc. (United States)


Published in SPIE Proceedings Vol. 6007:
Smart Medical and Biomedical Sensor Technology III
Brian M. Cullum; J. Chance Carter, Editor(s)

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