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Proceedings Paper

The susceptibility of bacteria to photodynamic inactivation with lanthanide complexes of chlorin e6
Author(s): Artur Bednarkiewicz; Zuzanna Drulis-Kawa; Rafal Wiglusz; Janina Legendziewicz; Gabriela Bugla-Ploskonska; Wlodzimierz Doroszkiewicz; Manfred Haupt; Wieslaw Strek
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Paper Abstract

Photodynamic inactivation (PDI) may be a very promising alternative method for antimicrobial treatment of many localised infections. In the present study we report the activity of three lanthanides (Eu(III), Pr(III), Yb(III)) complexes of Fotolon sensitizer, composed of chlorin e6 and polyvinylpyrrolidone (PVP), against standard E.coli P. aeruginosa, K. pneumoniae and S. aureus ATCC strains. The 160±10mW/cm2 of 651 nm laser light was applied for 600 seconds after photosensitiser administration (50μg/ml) and 30 minutes incubation time. Impact of pure Fotolon and pure lanthanides solution was examined as control groups.

Paper Details

Date Published: 27 August 2005
PDF: 6 pages
Proc. SPIE 5863, Therapeutic Laser Applications and Laser-Tissue Interactions II, 58630V (27 August 2005); doi: 10.1117/12.633092
Show Author Affiliations
Artur Bednarkiewicz, Institute of Low Temperatures and Structure Research (Poland)
Zuzanna Drulis-Kawa, Institute of Genetics and Microbiology, Univ. of Wroclaw (Poland)
Korczak Children's Hospital in Wroclaw (Poland)
Rafal Wiglusz, Univ. of Wroclaw (Poland)
Janina Legendziewicz, Univ. of Wroclaw (Poland)
Gabriela Bugla-Ploskonska, Institute of Genetics and Microbiology, Univ. of Wroclaw (Poland)
Wlodzimierz Doroszkiewicz, Institute of Genetics and Microbiology, Univ. of Wroclaw (Poland)
Manfred Haupt, Haemato-Polska Ltd. (Poland)
Wieslaw Strek, Institute of Low Temperatures and Structure Research (Poland)


Published in SPIE Proceedings Vol. 5863:
Therapeutic Laser Applications and Laser-Tissue Interactions II
Hubert van den Bergh; Alfred Vogel, Editor(s)

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