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Proceedings Paper

Pre-treatment dosimetry for interstitial photodynamic therapy
Author(s): A. Johansson; J. Hjelm; A. Eriksson; S. Andersson-Engels
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Paper Abstract

A genetic algorithm for optimal placement of optical fibers in arbitrary geometries for interstitial photodynamic therapy has been developed. Based on calculated fiber positions, the diffuse light distribution is simulated by solving the diffusion equation by means of the finite element method and the treatment time is calculated. Utilizing an instrument for interstitial photodynamic therapy that is capable of both delivering the therapeutic irradiation and measuring parameters of relevance to treatment monitoring, knowledge has been gained on temporal variations of tissue light absorption, sensitizer photobleaching and tissue oxygenation status. We speculate on how variations in these three parameters can be implemented in a crude pre-treatment dosimetry model for photodynamic therapy.

Paper Details

Date Published: 26 August 2005
PDF: 11 pages
Proc. SPIE 5863, Therapeutic Laser Applications and Laser-Tissue Interactions II, 58630S (26 August 2005); doi: 10.1117/12.633089
Show Author Affiliations
A. Johansson, Lund Institute of Technology (Sweden)
J. Hjelm, Lund Institute of Technology (Sweden)
A. Eriksson, Lund Institute of Technology (Sweden)
S. Andersson-Engels, Lund Institute of Technology (Sweden)

Published in SPIE Proceedings Vol. 5863:
Therapeutic Laser Applications and Laser-Tissue Interactions II
Hubert van den Bergh; Alfred Vogel, Editor(s)

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