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Proceedings Paper

Nerve regeneration in C. elegans after femtosecond laser axotomy
Author(s): Mehmet Fatih Yanik; Hulusi Cinar; Hediye Nese Cinar; Andrew D. Chisholm; Yishi Jin; Adela Ben-Yakar
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Paper Abstract

We show sub-micron scale surgery with femtosecond lasers in a tiny living organism. By just cutting few nano-scale nerve connections inside the nematode C. elegans, we can stop the whole worm from moving backwards. This delicate axotomy keeps the surrounding of the severed axons un-damaged so that the axons can regrow back, and the worms recover and can move backwards again. These results demonstrate, for the first time, nerve regeneration in such a tiny organism, in its evolutionarily simplest form. The ability to perform precise sub-micron scale axotomy on such organisms provides tremendous research potential for rapid screening of drugs and discovery of new biomolecules affecting regeneration and development.

Paper Details

Date Published: 26 August 2005
PDF: 8 pages
Proc. SPIE 5863, Therapeutic Laser Applications and Laser-Tissue Interactions II, 58630C (26 August 2005); doi: 10.1117/12.633081
Show Author Affiliations
Mehmet Fatih Yanik, Stanford Univ. (United States)
Hulusi Cinar, Univ. of California, Santa Cruz (United States)
Hediye Nese Cinar, Univ. of California, Santa Cruz (United States)
Andrew D. Chisholm, Univ. of California, Santa Cruz (United States)
Yishi Jin, Univ. of California, Santa Cruz (United States)
Howard Hughes Medical Institute (United States)
Adela Ben-Yakar, Univ. of Texas at Austin (United States)


Published in SPIE Proceedings Vol. 5863:
Therapeutic Laser Applications and Laser-Tissue Interactions II
Hubert van den Bergh; Alfred Vogel, Editor(s)

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