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Proceedings Paper

Glucose content monitoring with time-of-flight technique in aqueous intralipid solution imitating human skin: Monte Carlo simulation
Author(s): Alexey P. Popov; Alexander V. Priezzhev; Risto Myllyla
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Paper Abstract

Glucose content monitoring is of great importance today due to a number of people suffering from diabetes. In this paper, laser pulses propagation in a sample of aqueous Intralipid solution with glucose is simulated by Monte Carlo method. Effect of glucose is based on refractive index matching of Intralipid vesicles and surrounding water if glucose is added. Temporal profiles of femtosecond pulses (906 nm) diffusely scattered within a 2-mm thick plain glass cuvette with a skin phantom are registered in backward direction by two fiber-optics detectors 0.30 mm in diameter with numerical apertures of 0.19, 0.29, and 0.39. It is revealed that glucose content within the physiological range (100-500 mg/dl) can be detected because of the effect of glucose on the peak pulse intensity and on the area under the pulse temporal profile (energy of the registered pulse).

Paper Details

Date Published: 7 October 2005
PDF: 4 pages
Proc. SPIE 5862, Diagnostic Optical Spectroscopy in Biomedicine III, 586214 (7 October 2005); doi: 10.1117/12.633045
Show Author Affiliations
Alexey P. Popov, M.V. Lomonosov Moscow State Univ. (Russia)
Univ. of Oulu (Finland)
Infotech Oulu (Finland)
Alexander V. Priezzhev, M.V. Lomonosov Moscow State Univ. (Russia)
Risto Myllyla, Univ. of Oulu (Finland)
Infotech Oulu (Finland)

Published in SPIE Proceedings Vol. 5862:
Diagnostic Optical Spectroscopy in Biomedicine III
Mary-Ann Mycek, Editor(s)

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