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Proceedings Paper

Raman spectroscopy: development of clinical applications for breast cancer diagnosis
Author(s): Maryann Fitzmaurice; Abigail A. Haka; Zoya Volynskaya; Jason T. Motz; Joseph A. Gardecki; Jon Nazemi; Nancy Wang; Nina Klein; Robert Shenk; Joan Woletz; David Hicks; Joseph P. Crowe; Ramachnadra R. Dasari; Michael S. Feld
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Paper Abstract

Currently breast cancer diagnosis is made clinically through triple assessment: annual clinical breast examination, x-ray mammography or breast ultrasound imaging, and biopsy. The majority of women with suspicious breast lesions undergo either stereotactic (needle) or surgical (excisional) biopsy. Due to a high incidence of "false positives" at clinical breast diagnosis and "false negatives" at surgery, a large number of women undergo unnecessary and costly breast surgery. We describe our program of development of techniques and instrumentation for clinical application of NIR Raman spectroscopy for improved breast cancer diagnosis.

Paper Details

Date Published: 8 October 2005
PDF: 4 pages
Proc. SPIE 5862, Diagnostic Optical Spectroscopy in Biomedicine III, 586201 (8 October 2005); doi: 10.1117/12.633003
Show Author Affiliations
Maryann Fitzmaurice, Univ. Hospitals of Cleveland (United States)
Case Western Reserve Univ. (United States)
Abigail A. Haka, Massachussetts Institute of Technology (United States)
Zoya Volynskaya, Massachussetts Institute of Technology (United States)
Jason T. Motz, Massachussetts Institute of Technology (United States)
Joseph A. Gardecki, Massachussetts Institute of Technology (United States)
Jon Nazemi, Massachussetts Institute of Technology (United States)
Nancy Wang, Univ. Hospitals of Cleveland (United States)
Case Western Reserve Univ. (United States)
Nina Klein, Univ. Hospitals of Cleveland (United States)
Case Western Reserve Univ. (United States)
Robert Shenk, Univ. Hospitals of Cleveland (United States)
Case Western Reserve Univ. (United States)
Joan Woletz, The Cleveland Clinic Foundation (United States)
David Hicks, The Cleveland Clinic Foundation (United States)
Joseph P. Crowe, The Cleveland Clinic Foundation (United States)
Ramachnadra R. Dasari, Massachussetts Institute of Technology (United States)
Michael S. Feld, Massachussetts Institute of Technology (United States)


Published in SPIE Proceedings Vol. 5862:
Diagnostic Optical Spectroscopy in Biomedicine III
Mary-Ann Mycek, Editor(s)

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