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Proceedings Paper

Common-path Fourier domain optical coherence tomography of irradiated human skin and ventilated isolated rabbit lungs
Author(s): A. Popp; M. Wendel; L. Knels; P. Knuschke; M. Mehner; T. Koch; D. Boller D.V.M.; P. Koch; E. Koch
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Paper Abstract

A compact common path Fourier domain optical coherence tomography (FD-OCT) system based on a broadband superluminescence diode is used for biomedical imaging. The epidermal thickening of human skin after exposure to ultraviolet radiation is measured to proof the feasibility of FD-OCT for future substitution of invasive biopsies in a long term study on natural UV skin protection. The FD-OCT system is also used for imaging lung parenchyma. FD-OCT images of a formalin fixated lung show the same alveolar structure as scanning electron microscopy images. In the ventilated and blood-free perfused isolated rabbit lung FD-OCT is used for real-time cross-sectional image capture of alveolar mechanics throughout tidal ventilation. The alveolar mechanics changing from alternating recruitment-derecruitment at zero positive end-expiratory pressure (PEEP) to persistent recruitment after applying a PEEP of 5 cm H2O is observed in the OCT images.

Paper Details

Date Published: 7 October 2005
PDF: 9 pages
Proc. SPIE 5861, Optical Coherence Tomography and Coherence Techniques II, 58610Q (7 October 2005); doi: 10.1117/12.632984
Show Author Affiliations
A. Popp, Medizinische Fakultat TU Dresden (Germany)
M. Wendel, Medizinische Fakultat TU Dresden (Germany)
L. Knels, Medizinische Fakultat TU Dresden (Germany)
P. Knuschke, Universitatsklinikum Dresden (Germany)
M. Mehner, Medizinische Fakultat TU Dresden (Germany)
T. Koch, Medizinische Fakultat TU Dresden (Germany)
D. Boller D.V.M., Medizinisches Laserzentrum Luebeck GmbH (Germany)
P. Koch, Medizinisches Laserzentrum Luebeck GmbH (Germany)
E. Koch, TU Dresden (Germany)

Published in SPIE Proceedings Vol. 5861:
Optical Coherence Tomography and Coherence Techniques II
Wolfgang Drexler, Editor(s)

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