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Proceedings Paper

The 3-D collagen structure of equine articular cartilage, characterized using variable-angle-of-incidence polarization-sensitive optical coherence tomography
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Paper Abstract

Polarization-sensitive optical coherence tomography has been used to spatially map the birefringence of equine articular cartilage. Images obtained in the vicinity of visible osteoarthritic lesions display a characteristic disruption of the regular birefringence bands shown by normal cartilage. We also note that significant (e.g. ×2) variations in the apparent birefringence of samples taken from young (18 month) animals that otherwise appear visually homogeneous are found over spatial scales of a few millimeters. We suggest that whilst some of this variation may be due to changes in the intrinsic birefringence of the tissue, the 3-D orientation of the collagen fibers relative to the plane of the joint surface should also be taken into account. We propose a method based on multiple angles of illumination to determine the polar angle of the collagen fibers.

Paper Details

Date Published: 29 August 2005
PDF: 8 pages
Proc. SPIE 5861, Optical Coherence Tomography and Coherence Techniques II, 58610J (29 August 2005); doi: 10.1117/12.632977
Show Author Affiliations
Nadya Ugryumova, Univ. of Exeter (United Kingdom)
Sergei V. Gangnus, Univ. of Exeter (United Kingdom)
Stephen J. Matcher, Univ. of Exeter (United Kingdom)

Published in SPIE Proceedings Vol. 5861:
Optical Coherence Tomography and Coherence Techniques II
Wolfgang Drexler, Editor(s)

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