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Proceedings Paper

Improvements in brain activation detection using time-resolved diffuse optical means
Author(s): Bruno Montcel; Renee Chabrier; Patrick Poulet
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Paper Abstract

An experimental method based on time-resolved absorbance difference is described. The absorbance difference is calculated over each temporal step of the optical signal with the time-resolved Beer-Lambert law. Finite element simulations show that each step corresponds to a different scanned zone and that cerebral contribution increases with the arrival time of photons. Experiments are conducted at 690 and 830 nm with a time-resolved system consisting of picosecond laser diodes, micro-channel plate photo-multiplier tube and photon counting modules. The hemodynamic response to a short finger tapping stimulus is measured over the motor cortex. Time-resolved absorbance difference maps show that variations in the optical signals are not localized in superficial regions of the head, which testify for their cerebral origin. Furthermore improvements in the detection of cerebral activation is achieved through the increase of variations in absorbance by a factor of almost 5 for time-resolved measurements as compared to non-time-resolved measurements.

Paper Details

Date Published: 7 October 2005
PDF: 7 pages
Proc. SPIE 5859, Photon Migration and Diffuse-Light Imaging II, 58590G (7 October 2005); doi: 10.1117/12.632836
Show Author Affiliations
Bruno Montcel, Institut Physique Biologique, ULP/CNRS (France)
Renee Chabrier, Institut Physique Biologique, ULP/CNRS (France)
Patrick Poulet, Institut Physique Biologique, ULP/CNRS (France)

Published in SPIE Proceedings Vol. 5859:
Photon Migration and Diffuse-Light Imaging II
Kai Licha; Rinaldo Cubeddu, Editor(s)

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