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Proceedings Paper

System for the measurement of blood flow and oxygenation in tissue applied to neurovascular coupling in brain
Author(s): Matthias Kohl-Bareis; Christoph Leithner; Heike Sellien; Roland Guertler; Dmitri Geraskin; Benjamin Rohrer; Georg Royl; Ulrich Dirnagl; Ute Lindauer
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Paper Abstract

We designed a system incorporating the independent measurement of blood flow and oxygenation of haemoglobin. This is based on laser-Doppler spectroscopy with NIR wavelengths which gives a measure for changes in blood flow or tissue perfusion as well as reflectance spectroscopy in the VIS wavelength range for the calculation of the oxygenated and deoxygenated haemoglobin components. The co-registration of these parameters allows the neurovascular coupling of brain to be investigated. This is demonstrated by recording functional activity of the rat brain during electrical forepaw stimulation.

Paper Details

Date Published: 7 October 2005
PDF: 7 pages
Proc. SPIE 5859, Photon Migration and Diffuse-Light Imaging II, 58590F (7 October 2005); doi: 10.1117/12.632835
Show Author Affiliations
Matthias Kohl-Bareis, Univ. of Applied Sciences Koblenz (Germany)
Christoph Leithner, Humboldt Univ. Charite Hospital (Germany)
Heike Sellien, Humboldt Univ. Charite Hospital (Germany)
Roland Guertler, Univ. of Applied Sciences Koblenz (Germany)
Dmitri Geraskin, Univ. of Applied Sciences Koblenz (Germany)
Benjamin Rohrer, Univ. of Applied Sciences Koblenz (Germany)
Georg Royl, Humboldt Univ. Charite Hospital (Germany)
Ulrich Dirnagl, Humboldt Univ. Charite Hospital (Germany)
Ute Lindauer, Humboldt Univ. Charite Hospital (Germany)


Published in SPIE Proceedings Vol. 5859:
Photon Migration and Diffuse-Light Imaging II
Kai Licha; Rinaldo Cubeddu, Editor(s)

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