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Proceedings Paper

In vivo application of 2-D lateral scanning mode optical coherence tomography for glucose sensing
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Paper Abstract

Optical Coherence Tomography (OCT) was recently proposed by our group for noninvasive, continuous monitoring of blood glucose concentration in diabetics as well as in critically ill patients (both diabetic and nondiabetic). In our previous studies we tested OCT-based glucose sensing using one-dimensional (1-D) lateral scanning of the OCT probing beam over the tissue surface. The measured OCT signal was prone to motion artifacts and had high level of speckle noise. In this study we used two-dimensional (2-D) lateral scanning of the OCT probing beam and achieved 3.6-fold reduction of the speckle noise level. We also applied a post-processing Fourier filtration technique that resulted in an additional 2-2.5-fold suppression of noise. Our data indicate that the combination of acquisition time of 30-40s and the Fourier filtration technique may provide OCT monitoring of blood glucose concentration with a sensitivity of 1mM (18 mg/dL).

Paper Details

Date Published: 12 November 2005
PDF: 6 pages
Proc. SPIE 6007, Smart Medical and Biomedical Sensor Technology III, 60070K (12 November 2005); doi: 10.1117/12.630840
Show Author Affiliations
Roman Kuranov, Univ. of Texas Medical Branch (United States)
Donald Prough, Univ. of Texas Medical Branch (United States)
Veronika Sapozhnikova, Univ. of Texas Medical Branch (United States)
Inga Cicenaite, Univ. of Texas Medical Branch (United States)
Rinat Esenaliev, Univ. of Texas Medical Branch (United States)


Published in SPIE Proceedings Vol. 6007:
Smart Medical and Biomedical Sensor Technology III
Brian M. Cullum; J. Chance Carter, Editor(s)

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