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Proceedings Paper

Microsphere based saliva diagnostics
Author(s): David M. Rissin; Christopher DiCesare; Ryan B. Hayman; Timothy M. Blicharz; David R. Walt
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Paper Abstract

Saliva presents a minimally invasive alternative medium to blood for performing diagnostics1. Microsphere sensors for ions, small organic molecules, and proteins are currently being developed and optical microarrays containing thousands of these sensors will be used for simultaneous multi-analyte analysis. The fiber bundle platform in use is 1mm in diameter and contains approximately 50,000 individually addressable 3.1μm fibers, each with an etched well capable of housing a single 3.1μm microsphere sensor. Micron-sized bead-based chemistries are produced in house, followed by deposition onto a fiber-optic bundle platform, allowing for multiplexed analysis. The ultimate goal is to develop a universal diagnostic system using saliva as the diagnostic medium. This platform will permit multiplexed analysis of a sample by integrating microfluidics with the optical arrays loaded with sensors capable of detecting relevant biomarkers associated with a wide range of disease states. Disease states that are currently under investigation include end stage renal disease (ESRD) and Sjoegrens Syndrome (SS).

Paper Details

Date Published: 11 November 2005
PDF: 6 pages
Proc. SPIE 6007, Smart Medical and Biomedical Sensor Technology III, 60070X (11 November 2005); doi: 10.1117/12.630781
Show Author Affiliations
David M. Rissin, Tufts Univ. (United States)
Christopher DiCesare, Tufts Univ. (United States)
Ryan B. Hayman, Tufts Univ. (United States)
Timothy M. Blicharz, Tufts Univ. (United States)
David R. Walt, Tufts Univ. (United States)

Published in SPIE Proceedings Vol. 6007:
Smart Medical and Biomedical Sensor Technology III
Brian M. Cullum; J. Chance Carter, Editor(s)

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