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Proceedings Paper

Amplified electrocatalysis at DNA-modified nanowires for ultrasensitive biosensing
Author(s): Melissa A. Lapierre-Devlin; Shana O. Kelley
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Paper Abstract

Three-dimensional gold nanowire ensembles (NEE) are a novel and useful platform for electrochemical DNA detection. Work performed in our laboratory using the three-dimensional nanostructures with an electrocatalytic reporter system has produced attomole sensitivity towards target DNA sequences. Large electrocatalytic signals observed at DNA-modified nanowires produce high signal-to-noise ratios, which is one factor that contributes to the improved sensitivity. DNA- modified nanostructures generate amplified electrocatalysis signals that are significantly larger than those observed at bulk gold surfaces, and our experiments indicate that the three-dimensional architectures of the nanowires facilitate the electrocatalytic reaction because of enhanced diffusion and accessibility occurring around these structures. The heightened sensitivity achieved indicates that the nanowire ensembles constitute a promising platform for ultrasensitive biosensors.

Paper Details

Date Published: 11 November 2005
PDF: 10 pages
Proc. SPIE 6007, Smart Medical and Biomedical Sensor Technology III, 600705 (11 November 2005); doi: 10.1117/12.630723
Show Author Affiliations
Melissa A. Lapierre-Devlin, Boston College (United States)
Shana O. Kelley, Boston College (United States)

Published in SPIE Proceedings Vol. 6007:
Smart Medical and Biomedical Sensor Technology III
Brian M. Cullum; J. Chance Carter, Editor(s)

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