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Proceedings Paper

Detection of cephradine through the electrochemical study of the degradation product of cephradine
Author(s): Qingfeng Jiang; Yibin Ying; Jianping Wang; Zunzhong Ye; Yanbin Li
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Paper Abstract

The degradation product of cephradine(CEP), a broad spectrum antibiotic, with NaOH was studied in solution by Cyclic Voltammetry and Differential Pulse Voltammetry at a three electrode system (Gold working electrode, Hg/HgCl reference electrode and Platinum counter electrode). Our experiment was based on that the R-SH in degradation product could cause a deoxidization peak at gold working electrode. The response was optimized with respect to accumulation time, ionic strength, drug concentration, reproducibility and other variables. We found that the degradation product of CEP in Na2HPO4-NaH2PO4 buffer could cause a sensitive deoxidization peak at -0.68V. A linear dependence of peak currents on the concentration was observed in the range of 10-7 - 10-6 mol/L, with a detection limit of 0.5*10-7mol/L. This method can achieve satisfactory results in the application of detecting human-made CEP.

Paper Details

Date Published: 9 November 2005
PDF: 8 pages
Proc. SPIE 5994, Chemical and Biological Sensors for Industrial and Environmental Security, 59940V (9 November 2005); doi: 10.1117/12.630648
Show Author Affiliations
Qingfeng Jiang, Zhejiang Univ. (China)
Yibin Ying, Zhejiang Univ. (China)
Jianping Wang, Zhejiang Univ. (China)
Zunzhong Ye, Zhejiang Univ. (China)
Yanbin Li, Zhejiang Univ. (China)

Published in SPIE Proceedings Vol. 5994:
Chemical and Biological Sensors for Industrial and Environmental Security
Arthur J. Sedlacek III; Steven D. Christesen; Roger J. Combs; Tuan Vo-Dinh, Editor(s)

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