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Proceedings Paper

Terahertz biochip based on optoelectronic devices
Author(s): Ja-Yu Lu; Li-Jin Chen; Tzeng-Fu Kao; Hsu-Hao Chang; An-Shyi Liu; Yi-Chun Yu; Ruey-Beei Wu; Wei-Sheng Liu; Jen-Inn Chyi; Ci-Ling Pan; Ming-Cheng Tsai; Chi-Kuang Sun
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Paper Abstract

The accurate detection of minute amounts of chemical and biological substances has been a major goal in bioanalytical technology throughout the twentieth century. Fluorescence dye labeling detection remains the effective analysis method, but it modifies the surroundings of molecules and lowering the precision of detection. An alternative label free detecting tool with little disturbance of target molecules is highly desired. Theoretical calculations and experiments have demonstrated that many biomolecules have intrinsic resonance due to vibration or rotation level transitions, allowing terahertz (THz)-probing technique as a potential tool for the label-free and noninvasive detection of biomolecules. In this paper, we first ever combined the THz optoelectronic technique with biochip technology to realize THz biosensing. By transferring the edge-coupled photonic transmitter into a thin glass substrate and by integrating with a polyethylene based biochip channel, near field THz detection of the biomolecules is demonstrated. By directly acquiring the absorption micro-spectrum in the THz range, different boiomecules can then be identified according to their THz fingerprints. For preliminary studies, the capability to identity different illicit drug powders is successfully demonstrated. This novel biochip sensing system has the advantages including label-free detection, high selectivity, high sensitivity, ease for sample preparation, and ease to parallel integrate with other biochip functionality modules. Our demonstrated detection capability allows specifying various illicit drug powders with weight of nano-gram, which also enables rapid identification with minute amounts of other important molecules including DNA, biochemical agents in terrorism warfare, explosives, viruses, and toxics.

Paper Details

Date Published: 25 October 2005
PDF: 8 pages
Proc. SPIE 6013, Optoelectronic Devices: Physics, Fabrication, and Application II, 60130I (25 October 2005); doi: 10.1117/12.630033
Show Author Affiliations
Ja-Yu Lu, National Taiwan Univ. (Taiwan)
Li-Jin Chen, National Taiwan Univ. (Taiwan)
Tzeng-Fu Kao, National Taiwan Univ. (Taiwan)
Hsu-Hao Chang, National Taiwan Univ. (Taiwan)
An-Shyi Liu, National Taiwan Univ. (Taiwan)
Yi-Chun Yu, National Taiwan Univ. (Taiwan)
Ruey-Beei Wu, National Taiwan Univ. (Taiwan)
Wei-Sheng Liu, National Central Univ. (Taiwan)
Jen-Inn Chyi, National Central Univ. (Taiwan)
Ci-Ling Pan, National Chiao Tung Univ. (Taiwan)
Ming-Cheng Tsai, National Taiwan Univ. (Taiwan)
Chi-Kuang Sun, National Taiwan Univ. (Taiwan)

Published in SPIE Proceedings Vol. 6013:
Optoelectronic Devices: Physics, Fabrication, and Application II
Joachim Piprek, Editor(s)

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