Share Email Print

Proceedings Paper

Optical coherence tomography for imaging of chronic total occlusions
Author(s): Nigel R. Munce; Victor X. D. Yang; Beiping Qiang; Brian K. Courtney; Lukasz Brzozowski; Ludmilla Bakueva; Linda Y. Mao; Beau Standish; Jagdish Butany; Alexander J. Dick; Bradley H. Strauss; Graham A. Wright; Alex Vitkin
Format Member Price Non-Member Price
PDF $14.40 $18.00
cover GOOD NEWS! Your organization subscribes to the SPIE Digital Library. You may be able to download this paper for free. Check Access

Paper Abstract

Chronic total occlusions (CTOs) are defined as complete occlusions of an artery older than one month. Minimally invasive catheter-based interventions commonly employed for partial occlusions (e.g., balloon angioplasty followed by stenting) are problematic in CTOs because of the phycisian's inability to pass the device through the occlusion without a significant risk of arterial wall perforations. Furthermore, successfully treated CTOs exhibit a high re-occlusion rate. As a result, these cases are mostly sent to bypass surgery. With the advent of drug-eluting stents that reduce the incidence of re-occlusion, and thus, eliminating the second problem, new devices have begun to emerge that aim to recanalize CTOs without the cost and trauma of bypass surgery. These devices, however, need effective image guidance methods to ensure successful crossing of the CTOs. Optical coherence tomography (OCT) is being evaluated as an intravascular imaging modality for guiding catheter-based interventions of CTOs. Occluded ex vivo human arterial samples were used to produce longitudinal cross-sections using an OCT system. These OCT images were compared with histology to assess OCT's ability to identify different components of the occluded artery, evaluate the imaging depth, and determine the ability to detect the underlying vessel wall. Given the inherent difficulties of creating a mechanically scanning OCT probe in the distal tip of a catheter for use in a stenotic artery, we directed our initial efforts towards developing a "motionless" fiber based OCT system using a single mode fiber array. We discuss design considerations for implementing a forward viewing intravascular OCT probe.

Paper Details

Date Published: 13 October 2005
PDF: 8 pages
Proc. SPIE 5969, Photonic Applications in Biosensing and Imaging, 59691S (13 October 2005); doi: 10.1117/12.628582
Show Author Affiliations
Nigel R. Munce, Univ. of Toronto (Canada)
Victor X. D. Yang, Univ. of Toronto (Canada)
Beiping Qiang, Terrence Donelly Heart Ctr./Saint Michael's Hospital (Canada)
Brian K. Courtney, Univ. of Toronto (Canada)
Lukasz Brzozowski, Sunnybrook Health Science Ctr. (Canada)
Ludmilla Bakueva, Sunnybrook Health Science Ctr. (Canada)
Linda Y. Mao, Univ. of Toronto (Canada)
Beau Standish, Univ. of Toronto (Canada)
Jagdish Butany, Univ. of Toronto (Canada)
Alexander J. Dick, Sunnybrook Health Science Ctr. (Canada)
Bradley H. Strauss, Terrence Donelly Heart Ctr./Saint Michael's Hospital (Canada)
Graham A. Wright, Sunnybrook Health Science Ctr. (Canada)
Alex Vitkin, Univ. of Toronto (Canada)

Published in SPIE Proceedings Vol. 5969:
Photonic Applications in Biosensing and Imaging
Brian C. Wilson; Richard I. Hornsey; Warren C. W. Chan; Ulrich J. Krull; Robert A. Weersink; Kui Yu, Editor(s)

© SPIE. Terms of Use
Back to Top