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Proceedings Paper

Integrated optical detection subsystem for functional genomic analysis biosensor
Author(s): Corinne Vergnenègre; Thierry Camps; Véronique Bardinal; Charlotte Bringer; Chantal Fontaine; Antonio Muñoz-Yagüe
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Paper Abstract

We present an optical microsystem aimed to be integrated into a nanomechanical biosensor for functional genomic analysis. The operation principle is based on a sub-nanometer resolution optical measurement of a cantilever deflection caused by a surface stress when the target nucleic acid sample hybridises to the nucleic acid probe on the active side of the cantilever. The resulting deflection, of the order of nanometers, is measured by an optical system, in which a laser beam reflects off the back of the cantilever to a position sensitive photo-detector. We report in this paper on the design, fabrication and test of the optical head associated with an optical coupling system which enables detection of the presence of target nucleic acid on the cantilever by amplifying the deflection caused by the stress.

Paper Details

Date Published: 13 October 2005
PDF: 10 pages
Proc. SPIE 5969, Photonic Applications in Biosensing and Imaging, 596912 (13 October 2005); doi: 10.1117/12.628297
Show Author Affiliations
Corinne Vergnenègre, LAAS-CNRS (France)
Thierry Camps, LAAS-CNRS (France)
Véronique Bardinal, LAAS-CNRS (France)
Charlotte Bringer, LAAS-CNRS (France)
Chantal Fontaine, LAAS-CNRS (France)
Antonio Muñoz-Yagüe, LAAS-CNRS (France)

Published in SPIE Proceedings Vol. 5969:
Photonic Applications in Biosensing and Imaging
Brian C. Wilson; Richard I. Hornsey; Warren C. W. Chan; Ulrich J. Krull; Robert A. Weersink; Kui Yu, Editor(s)

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