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Proceedings Paper

The use of surface enhanced absorption, scattering and catalytic properties of gold nanoparticles in some bio- and biomedical applications
Author(s): Xiaohua Huang; Ivan H El-Sayed; Mostafa A. El-Sayed
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Paper Abstract

Gold nanoparticles with unique optical properties offer useful applications in biotechnology. In this article two applications that we have developed are summarized, in one they are used in cancer cell diagnostics and in the other they are found to have catalytic property for the NADH oxidation reaction which is important in ATP formations. By conjugation with anti-EGFR antibodies which specifically target EGFR that are usually overexpressed on most cancer cells, gold nanoparticles are used as a molecular contrast agent for cancer cell diagnostics using their both strong surface plasmon absorption and efficient Mie scattering properties. Au nanoparticles are also good catalysts for many reactions due to their high surface to volume ratio. Au nanoparticles are found to be the catalyst for the NADH oxidation reaction. This was studied by monitoring the effect of the nanoparticles on NADH fluorescence intensity and lifetime as well as the change of the surface plasmon absorption band during the reaction.

Paper Details

Date Published: 18 August 2005
PDF: 10 pages
Proc. SPIE 5929, Physical Chemistry of Interfaces and Nanomaterials IV, 59290I (18 August 2005); doi: 10.1117/12.625431
Show Author Affiliations
Xiaohua Huang, Georgia Institute of Technology (United States)
Ivan H El-Sayed, Univ. of California/San Francisco (United States)
Mostafa A. El-Sayed, Georgia Institute of Technology (United States)

Published in SPIE Proceedings Vol. 5929:
Physical Chemistry of Interfaces and Nanomaterials IV
Clemens Burda; Randy J. Ellingson, Editor(s)

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