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Proceedings Paper

Label-free detection of biomolecules by waveguide interferometry
Author(s): Katrin Schmitt; Bernd Schirmer; Albrecht Brandenburg
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Paper Abstract

We report on a recently developed highly sensitive instrument for label-free detection of biomolecules based on the principle of a Young interferometer. With this technology, biomolecular interactions can be detected in real-time without elaborate sample preparation using a planar waveguide as sensing element. The binding reaction of the antibody-antigen pair immunoglobulin G and protein G has been studied and an affinity constant of K=2.6*107 M-1 has been determined.

Paper Details

Date Published: 23 May 2005
PDF: 4 pages
Proc. SPIE 5855, 17th International Conference on Optical Fibre Sensors, (23 May 2005); doi: 10.1117/12.623711
Show Author Affiliations
Katrin Schmitt, Fraunhofer-Institut fuer Physikalische Messtechnik (Germany)
Bernd Schirmer, Fraunhofer-Institut fuer Physikalische Messtechnik (Germany)
Albrecht Brandenburg, Fraunhofer-Institut fuer Physikalische Messtechnik (Germany)

Published in SPIE Proceedings Vol. 5855:
17th International Conference on Optical Fibre Sensors
Marc Voet; Reinhardt Willsch; Wolfgang Ecke; Julian Jones; Brian Culshaw, Editor(s)

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