Share Email Print
cover

Proceedings Paper

Force microscopy: application to soft matter
Author(s): Mounir Maaloum; Raphaël Levy
Format Member Price Non-Member Price
PDF $14.40 $18.00
cover GOOD NEWS! Your organization subscribes to the SPIE Digital Library. You may be able to download this paper for free. Check Access

Paper Abstract

Atomic force microscopy (AFM) has been shown to be a good means of investigating matter at the nanometer scale. Here, we use it on one hand to determine the structure of adsorbed biological macromolecules such as DNA at high resolution on solid surfaces in liquid, and on the other hand as a force probe. In this case, we try to extract the relevant information from the complicated force profiles. We have studied the characterisation of specific molecular interactions. Our study reveals that in the presence of multiple parallel bonds with high rebinding probability, the force increases with decreasing speed velocity. We propose that the rebinding via the fluctuation of the linker is responsible for the observed behaviour.

Paper Details

Date Published: 12 April 2005
PDF: 7 pages
Proc. SPIE 5852, Third International Conference on Experimental Mechanics and Third Conference of the Asian Committee on Experimental Mechanics, (12 April 2005); doi: 10.1117/12.621759
Show Author Affiliations
Mounir Maaloum, Univ. Louis Pasteur 6 (France)
Raphaël Levy, Univ. of Liverpool (United Kingdom)


Published in SPIE Proceedings Vol. 5852:
Third International Conference on Experimental Mechanics and Third Conference of the Asian Committee on Experimental Mechanics
Chenggen Quan; Fook Siong Chau; Anand Asundi; Brian Stephen Wong; Chwee Teck Lim, Editor(s)

© SPIE. Terms of Use
Back to Top