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Proceedings Paper

Two-dimensional surface plasmon resonance biosensor array based on phase-sensitive measurement
Author(s): H. P. Ho; K. S. Chan; C. L. Wong; K. F. Lei; W. J. Li; W. C. Law; S. Y. Wu; S. K. Kong; C. Lin
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Paper Abstract

We report a 2-dimensional surface plasmon resonance (SPR) imaging array sensor based on differential phase measurement between p- and s-polarization. This parallel detection provides the advantage of high-throughput sensing, which is essential in recent biosensing technology. In the differential measurement approach, the signal (p) and reference (s) beams go through exactly identical optical path. This greatly improves the phase detection stability. In the present setup we use a low-cost imaging device and a simple data analysis program to perform the required arrayed sensing operation. The system demonstrates a refractive index resolution of 1x10-4 RIU per degree phase change.

Paper Details

Date Published: 26 August 2005
PDF: 10 pages
Proc. SPIE 5927, Plasmonics: Metallic Nanostructures and Their Optical Properties III, 59270E (26 August 2005); doi: 10.1117/12.619180
Show Author Affiliations
H. P. Ho, The Chinese Univ. of Hong Kong (Hong Kong China)
K. S. Chan, City Univ. of Hong Kong (Hong Kong China)
C. L. Wong, The Chinese Univ. of Hong Kong (Hong Kong China)
City Univ. of Hong Kong (Hong Kong China)
K. F. Lei, The Chinese Univ. of Hong Kong (Hong Kong China)
W. J. Li, The Chinese Univ. of Hong Kong (Hong Kong China)
W. C. Law, The Chinese Univ. of Hong Kong (Hong Kong China)
S. Y. Wu, The Chinese Univ. of Hong Kong (Hong Kong China)
S. K. Kong, The Chinese Univ. of Hong Kong (Hong Kong China)
C. Lin, The Chinese Univ. of Hong Kong (Hong Kong China)


Published in SPIE Proceedings Vol. 5927:
Plasmonics: Metallic Nanostructures and Their Optical Properties III
Mark I. Stockman, Editor(s)

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