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Proceedings Paper

Using optical tweezers to examine the chemotactic force to a single inflammatory cell--eosinophil stimulated by chemoattractants prepared from Toxocara Canis larvae
Author(s): Po-Chen Shih; Yi-Jr Su; Ke-Min Chen; Lin-Ni Jen; Cheng-tzu Liu; Long Hsu
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Paper Abstract

Granulocytes are a group of white blood cells belonging to the innate immune system in human and in murine in which eosinophils play an important role in worm infection-induced inflammation. The migration of these cells is well characterized and has been separated into four steps: rolling, adhesion, transendothelial migration, and chemotaxis, however, the physical characteristics of the chemotactic force to eosinophils from worm component remain largely unknown. Note that optical tweezers are featured in the manipulation of a single cell and the measurement of biological forces. Therefore, we propose to use optical tweezers to examine the chemotactic force to a eosinophil from a T. canis lavae preparation in terms of distance during the migration of eosinophil.

Paper Details

Date Published: 27 August 2005
PDF: 9 pages
Proc. SPIE 5930, Optical Trapping and Optical Micromanipulation II, 59301R (27 August 2005); doi: 10.1117/12.616826
Show Author Affiliations
Po-Chen Shih, National Chiao-Tung Univ. (Taiwan)
Yi-Jr Su, National Chiao-Tung Univ. (Taiwan)
Ke-Min Chen, Chung Shan Medical Univ. (Taiwan)
Lin-Ni Jen, Chung Shan Medical Univ. (Taiwan)
Cheng-tzu Liu, Chung Shan Medical Univ. (Taiwan)
Long Hsu, National Chiao-Tung Univ. (Taiwan)


Published in SPIE Proceedings Vol. 5930:
Optical Trapping and Optical Micromanipulation II
Kishan Dholakia; Gabriel C. Spalding, Editor(s)

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