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Proceedings Paper

Nerve regeneration after femtosecond laser nanosurgery
Author(s): Mehmet Fatih Yanik; Hulusi Cinar; Hediye Nese Cinar; Andrew D. Chisholm; Yishi Jin; Adela Ben-Yakar
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Paper Abstract

We demonstrate sub-micron scale surgery with femtosecond lasers in a tiny living organism. By just cutting few nano-scale nerve connections inside the nematode C. elegans, we succeeded to stop the whole animal from moving backwards. This delicate axotomy keeps the surrounding of the severed axons un-damaged so that the axons can regrow back, and the worms recover and can move backwards again. These results demonstrate, for the first time, nerve regeneration in such a tiny organism, in its evolutionarily simplest form. The ability to perform precise sub-micron scale axotomy on such organisms provides tremendous research potential for rapid screening of drugs and discovery of new biomolecules affecting regeneration and development.

Paper Details

Date Published: 21 March 2005
PDF: 8 pages
Proc. SPIE 5714, Commercial and Biomedical Applications of Ultrafast Lasers V, (21 March 2005); doi: 10.1117/12.613174
Show Author Affiliations
Mehmet Fatih Yanik, Stanford Univ. (United States)
Hulusi Cinar, Univ. of California/Santa Cruz (United States)
Hediye Nese Cinar, Univ. of California/Santa Cruz (United States)
Andrew D. Chisholm, Univ. of California/Santa Cruz (United States)
Yishi Jin, Univ. of California/Santa Cruz (United States)
Univ. of Texas at Austin (United States)
Adela Ben-Yakar, Stanford Univ. (United States)


Published in SPIE Proceedings Vol. 5714:
Commercial and Biomedical Applications of Ultrafast Lasers V
Joseph Neev; Christopher B. Schaffer; Andreas Ostendorf; Stefan Nolte, Editor(s)

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