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Proceedings Paper

Microfabricated substrates for spectroscopy and separation
Author(s): Jennifer L. Sample; Stergios J. Papadakis; Michael J. Fitch; Joseph A. Miragliotta
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Paper Abstract

In this paper, we report the preliminary results from a microfabricated substrate system that is amenable to both electromagnetic field-enhanced spectroscopy such as surface enhanced Raman scattering (SERS) and analyte separation and detection. Substrates consisting of arrays of gold post-like and pit-like features of varying pitch on gold substrates were fabricated by electron beam lithography. These substrates were characterized and tested for reproducible SERS activity, as well as evaluated for incorporation into a microfluidic system for separation and identification of components of complex matrices. Identification of analytes relevant to biodetection and biological screening is reported.

Paper Details

Date Published: 29 March 2005
PDF: 8 pages
Proc. SPIE 5699, Imaging, Manipulation, and Analysis of Biomolecules and Cells: Fundamentals and Applications III, (29 March 2005); doi: 10.1117/12.612071
Show Author Affiliations
Jennifer L. Sample, Johns Hopkins Univ. (United States)
Stergios J. Papadakis, Johns Hopkins Univ. (United States)
Michael J. Fitch, Johns Hopkins Univ. (United States)
Joseph A. Miragliotta, Johns Hopkins Univ. (United States)


Published in SPIE Proceedings Vol. 5699:
Imaging, Manipulation, and Analysis of Biomolecules and Cells: Fundamentals and Applications III
Dan V. Nicolau; Dan V. Nicolau; Jörg Enderlein; Ramesh Raghavachari; Robert C. Leif; Daniel L. Farkas, Editor(s)

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