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Proceedings Paper

Are motor proteins power strokers, Brownian motors or both? (Invited Paper)
Author(s): Brian Geislinger; Erin Darnell; Kimberly Farris; Ryoichi Kawai
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Paper Abstract

About a decade ago Brownian motors were introduced as a possible mechanism for motor protein mobility. Since then many theoretical and experimental papers have been published on the topic. While some experiments support Brownian motor mechanisms, others are more consistent with traditional power stroke models. Taking into account recent experimental data and molecular level simulations, we have developed a stochastic model which incorporates both power stroke and Brownian motor mechanisms. Depending on parameter values, this motor works as a power stroker, a Brownian motor or a hybrid of the two. Using this model we investigate the motility of single-head myosins, two-head myosins and a group of myosins (muscle). The results are compared with some experimental data.

Paper Details

Date Published: 23 May 2005
PDF: 11 pages
Proc. SPIE 5845, Noise in Complex Systems and Stochastic Dynamics III, (23 May 2005); doi: 10.1117/12.609464
Show Author Affiliations
Brian Geislinger, Univ. of Alabama at Birmingham (United States)
Erin Darnell, Columbia Univ. (United States)
Kimberly Farris, Jefferson County International Baccalaureate (United States)
Ryoichi Kawai, Univ. of Alabama at Birmingham (United States)


Published in SPIE Proceedings Vol. 5845:
Noise in Complex Systems and Stochastic Dynamics III
Laszlo B. Kish; Katja Lindenberg; Zoltan Gingl, Editor(s)

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