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Proceedings Paper

Three new phthalocyanines with potential for PDT studies
Author(s): Boris D. Rihter; Maria D. Bohorquez; Michael A. J. Rodgers; Malcolm E. Kenney
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Paper Abstract

The synthesis and characterization of a tetradibenzobarrelenoocta-n-butoxyzinc phthalocyanine, as well as the phthalocyanines t-butyldimethylsiloxy-N(3(beta) -acetoxy-23, 24-dinor-5-cholenoyl)-4-amino-n-butyldimethylsiloxysilicon phthalocyanine and bis- N(3(beta) -acetoxy-23,24-dinor-5-cholenoyl)-4-amino-n-butyldimethylsiloxysilicon phthalocyanine are reported. The zinc phthalocyanine is soluble, open at its center and highly hindered. It has a deep red absorption and a long triplet state lifetime. The silicon phthalocyanines have red absorptions and ligands bearing functions that have a resemblance to a part of the core of the low density lipoprotein fraction of blood serum. The zinc phthalocyanine has the potential to be a good photosensitizer, and the silicon phthalocyanines or related compounds have the potential to be preferentially accumulated by tumor cells. All three compounds are of interest for photodynamic therapy studies.

Paper Details

Date Published: 1 June 1992
PDF: 8 pages
Proc. SPIE 1645, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy, (1 June 1992); doi: 10.1117/12.60946
Show Author Affiliations
Boris D. Rihter, Case Western Reserve Univ. (United States)
Maria D. Bohorquez, Bowling Green State Univ. (United States)
Michael A. J. Rodgers, Bowling Green State Univ. (United States)
Malcolm E. Kenney, Case Western Reserve Univ. (United States)


Published in SPIE Proceedings Vol. 1645:
Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy
Thomas J. Dougherty, Editor(s)

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