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Proceedings Paper

Promotion of porphyrin cytotoxicity by ultrasound (Invited Paper)
Author(s): David Kessel; Russell Jeffers; Charles A. Cain
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Paper Abstract

We examined the effect of ultrasound on the murine leukemia L1210 cell line in culture, in the presence of different photosensitizing agents: mesoporphyrin and tetraphenylporphines bearing 1 - 4 sulfonate groups. These agents could enhance ultrasound-induced cell damage when added to the incubation medium; sensitizers present only in the intracellular space were inactive in this regard. All of the porphine sulfonates were equally effective sensitizers to ultrasound but the product with 2 adjacent-SO3H groups was the most effective photodynamic sensitizer. Ultrasound-induced cytotoxicity was associated with outer membrane damage and could be detected by measuring hydrophobic- or charge-associated whole-cell partitioning or by measurement of inhibition of active transport of a non-metabolized amino acid.

Paper Details

Date Published: 1 June 1992
PDF: 9 pages
Proc. SPIE 1645, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy, (1 June 1992); doi: 10.1117/12.60930
Show Author Affiliations
David Kessel, Wayne State Univ. School of Medicine (United States)
Russell Jeffers, Univ. of Michigan (United States)
Charles A. Cain, Univ. of Michigan (United States)


Published in SPIE Proceedings Vol. 1645:
Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy
Thomas J. Dougherty, Editor(s)

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