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Proceedings Paper

Clinical, MRI, and histological results after photodynamic therapy of oral cancer
Author(s): Michael Herzog; Ch. Fellbaum; C. Wagner-Manslau; Hans-Henning Horch
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Paper Abstract

Twenty-one carcinomas of the oral cavity in 18 patients were treated by photodynamic therapy (PDT). Patients were sensitized with Photosan III (2 mg/kg body weight), a modified HPD. Forty-eight hours after application of Photosan III, the tumor and surrounding tissues were irradiated with red laser light (200 mW/cm2, 120 J/cm2). MRI controls were carried out 24 hours after irradiation. Three to five days after irradiation, tumors were removed by conventional surgery. All specimens underwent histological examination. Histologically, hemorrhagic necroses of the irradiated tumors was found in all cases. The depth of necrosis varied from 2 to 8 mm. By MRI controls it was possible to detect edemas as change of signal resonance. PDT is a reliable therapy to reduce oral cancer selectively. Cancer destruction is limited by penetration depth of the laser light.

Paper Details

Date Published: 1 June 1992
PDF: 4 pages
Proc. SPIE 1645, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy, (1 June 1992); doi: 10.1117/12.60927
Show Author Affiliations
Michael Herzog, Technische Univ. Muenchen (Germany)
Ch. Fellbaum, Technische Univ. Muenchen (Germany)
C. Wagner-Manslau, Technische Univ. Muenchen (Germany)
Hans-Henning Horch, Technische Univ. Muenchen (Germany)


Published in SPIE Proceedings Vol. 1645:
Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy
Thomas J. Dougherty, Editor(s)

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