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Proceedings Paper

Feasibility of intrapleural photodynamic therapy: the first eight patients (Invited Paper)
Author(s): Harvey I. Pass; Thomas F. DeLaney; Angelo Russo; James Mitchell; Paul D. Smith; Walter Friauf; Gunter F. Thomas
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Paper Abstract

Photodynamic therapy (PDT) is a surface oriented, locally cytotoxic intervention being investigated for oncologic therapy. Surfaces such as the pleura or the peritoneum are frequency involved with primary or metastatic cancer, and the chance for cure in such situations is low due to the inability to eradicate all the disease. A series of investigations has been performed at the National Cancer Institute since 1985 studying the possible use of PDT for large cavity treatment. This report details the original methodology, immediate results, and overall feasibility of the delivery of intrapleural PDT to patients after debulking of primary and malignant neoplasms in the chest which were considered to be 'non-curative' by standard surgical techniques alone. From this original feasibility study, an ongoing Phase I trial has developed to determine the maximum amount of this therapy which can be delivered safely to the thorax.

Paper Details

Date Published: 1 June 1992
PDF: 8 pages
Proc. SPIE 1645, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy, (1 June 1992); doi: 10.1117/12.60923
Show Author Affiliations
Harvey I. Pass, National Cancer Institute/NIH (United States)
Thomas F. DeLaney, National Cancer Institute/NIH (United States)
Angelo Russo, National Cancer Institute/NIH (United States)
James Mitchell, National Cancer Institute/NIH (United States)
Paul D. Smith, National Cancer Institute/NIH (United States)
Walter Friauf, National Cancer Institute/NIH (United States)
Gunter F. Thomas, National Cancer Institute/NIH (United States)


Published in SPIE Proceedings Vol. 1645:
Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy
Thomas J. Dougherty, Editor(s)

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