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Proceedings Paper

Preparation and biological investigation of luminescent water soluble CdTe nanoparticles
Author(s): Stephen J. Byrne; Ciara M. O'Driscoll; Serena A. Corr; Yurii K. Gun'ko; Siobhan Mitchell; Yuri Volkov
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Paper Abstract

In this study CdTe quantum dots have been successfully prepared in aqueous medium using several different thiol stabilizers. The resulting nanocrystals were purified and the photoluminescence efficiency was subsequently enhanced through post preparative procedures such as photochemical etching and ageing. An optical study was carried out on the resulting CdTe nanocrystals as proof as their improvement. Preliminary tests of the thiol stabilised QDs as potential biolabels have been performed. It has been shown that L-cysteine stabilised QDs localising to the outer cell membrane in living cells. TGA stabilised CdTe QDs can potentially serve as live cell imaging tools as they exhibit strong luminescence and excellent photostability. In addition, the ability of TGA stabilised CdTe QDs to traverse the cell membrane of macrophages is a formidable quality that may potentially be harnessed for imaging and therapeutics. Modulating the delivery of QDs to subcellular locations in living cells opens a myriad of potential applications ranging from drug delivery to examination of intracellular processes.

Paper Details

Date Published: 2 June 2005
PDF: 9 pages
Proc. SPIE 5824, Opto-Ireland 2005: Nanotechnology and Nanophotonics, (2 June 2005); doi: 10.1117/12.604814
Show Author Affiliations
Stephen J. Byrne, Univ. of Dublin, Trinity College (Ireland)
Ciara M. O'Driscoll, Univ. of Dublin, Trinity College (Ireland)
Serena A. Corr, Univ. of Dublin, Trinity College (Ireland)
Yurii K. Gun'ko, Univ. of Dublin, Trinity College (Ireland)
Siobhan Mitchell, Trinity College Dublin (Ireland)
Yuri Volkov, Trinity College Dublin (Ireland)

Published in SPIE Proceedings Vol. 5824:
Opto-Ireland 2005: Nanotechnology and Nanophotonics
David Kennedy; Werner J. Blau; John Colreavy, Editor(s)

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