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Proceedings Paper

An image-based computational model of ovine lung mechanics and ventilation distribution
Author(s): Merryn H. Tawhai; Martyn P. Nash; Juerg Tschirren; Eric A. Hoffman; Peter J. Hunter
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Paper Abstract

A computational model of soft tissue mechanics and air flow has been developed with the aim of linking computed tomography measures of ventilation distribution to subject-specific predictions in image-based geometric (finite element) models of the lung and airway tree. Computational techniques that can deal with anatomical detail and spatially-distributed non-linear material properties have been used to couple solution of parenchymal soft tissue mechanics in an anatomically-based model of the ovine lung to predictions of flow and pressure in an embedded model of the ovine airway tree. The lung is modeled as a homogeneous, compressible, non-linear elastic body. Using equations for large deformation mechanics, the change in geometry of the lung is simulated at static inflation pressures from 25 to 0 cmH2O. Multi-detector row computed tomography imaging has been used to define the model geometry (lung and airway), to define the movement of the model lung surface during inflation, and for measurements of internal material point displacements for comparison with the predicted internal displacements of the model. This preliminary model predicts airway bifurcation point displacements that are generally in agreement with imaged displacements (total RMS error for all bifurcation points is < 4 mm from 25 to 0 cm H2O). Further development of the model will provide a predictive link between subject-specific anatomical and functional information.

Paper Details

Date Published: 14 April 2005
PDF: 8 pages
Proc. SPIE 5746, Medical Imaging 2005: Physiology, Function, and Structure from Medical Images, (14 April 2005); doi: 10.1117/12.600723
Show Author Affiliations
Merryn H. Tawhai, Univ. of Auckland (New Zealand)
Martyn P. Nash, Univ. of Auckland (New Zealand)
Juerg Tschirren, Univ. of Iowa College of Medicine (United States)
Eric A. Hoffman, Univ. of Iowa College of Medicine (United States)
Peter J. Hunter, Univ. of Auckland (New Zealand)


Published in SPIE Proceedings Vol. 5746:
Medical Imaging 2005: Physiology, Function, and Structure from Medical Images
Amir A. Amini; Armando Manduca, Editor(s)

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