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Proceedings Paper

Bootstrapped MRMC confidence intervals
Author(s): Frank W. Samuelson; Robert F. Wagner
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Paper Abstract

The multiple-reader, multiple-case (MRMC) paradigm of Swets and Pickett (1982) for ROC analysis was expressed as a components of variance model by Dorfman, Berbaum, and Metz (1992) and validated by Roe and Metz (1997) for Type I error rates. Our group proposed an analysis of the MRMC components of variance model using bootstrap (Beiden, Wagner, and Campbell, 2000) experiments instead of jackknife pseudo-values. These approaches have been challenged by some contemporary authors (e.g. Zhou, Obuchowski, and McClish, 2002). The purpose of the present paper is to formally compare the models and to carry out validation tests of their performance. We investigate different approaches to statistical inference, including several types of nonparametric bootstrap confidence intervals and report on validation and simulation experiments of Type I errors.

Paper Details

Date Published: 6 April 2005
PDF: 6 pages
Proc. SPIE 5749, Medical Imaging 2005: Image Perception, Observer Performance, and Technology Assessment, (6 April 2005); doi: 10.1117/12.597660
Show Author Affiliations
Frank W. Samuelson, US FDA/CDRH (United States)
Robert F. Wagner, US FDA/CDRH (United States)

Published in SPIE Proceedings Vol. 5749:
Medical Imaging 2005: Image Perception, Observer Performance, and Technology Assessment
Miguel P. Eckstein; Yulei Jiang, Editor(s)

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