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Proceedings Paper

A pilot study on less-stressful bowel preparation for virtual colonoscopy screening with follow-up biopsy by optical colonoscopy
Author(s): Zhengrong Liang; Sarang Lakare; Mark Wax; Dongqing Chen; Lihong Li; Joseph Anderson; Arie Kaufman; Donald Harrington
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Paper Abstract

Objective: To investigate a less stressful bowel preparation for polyp screening by virtual colonoscopy (VC) with follow-up biopsy on the positive findings by optical colonoscopy (OC). Materials and Methods: Fifty-eight volunteers of age older than 40 -- receiving low-residue diet and laxatives of magnesium citrate, bisacodyl tablets and suppository -- were divided into three groups. In Group I, 16 volunteers took three 40cc oral doses of MD-Gastroview with the three meals respectively, the day prior to VC procedure. In Group II, 18 volunteers ingested barium sulfate suspension (2% w/v, 250 cc/dose) at bedtime and in the next day morning of VC. In Group III, 24 volunteers received 60 cc of MD-Gastroview at bedtime and in the next day morning of VC. Following colon inflation with CO2, computer tomography (CT) abdominal images were acquired by a standard single-slice detector-band VC protocol, i.e., 5 mm collimation, 1 mm reconstruction, 1.5-2.0:1.0 pitch, 120 kVp and 100-150 mA. The CT density of the tagged residual fluid was measured. An image segmentation algorithm was applied to remove electronically the residue fluid. Results: The average fluid density was 97 HU for Group I, 221 HU for Group II2, and 599 HU for Group III. These three groups’ density means are significantly different (p < 0.001 one-way ANOVA). After the electronic cleansing, the % of cleansed fluid regions was 5.5%, 16.5% and 93.1% (p<0.0001 Chi square) for these groups respectively. Conclusion: A less-stressful bowel preparation with low residue diet and MD-Gastroview oral contrast is feasible for VC screening with follow-up biopsy on the positive findings by OC.

Paper Details

Date Published: 14 April 2005
PDF: 7 pages
Proc. SPIE 5746, Medical Imaging 2005: Physiology, Function, and Structure from Medical Images, (14 April 2005); doi: 10.1117/12.597437
Show Author Affiliations
Zhengrong Liang, State Univ. of New York/Stony Brook (United States)
Sarang Lakare, State Univ. of New York/Stony Brook (United States)
Mark Wax, State Univ. of New York/Stony Brook (United States)
Good Samaritan Hospital Medical Ctr. (United States)
Dongqing Chen, Viatronix Inc. (United States)
Lihong Li, State Univ. of New York/Stony Brook (United States)
College of Staten Island/CUNY (United States)
Joseph Anderson, State Univ. of New York/Stony Brook (United States)
Arie Kaufman, State Univ. of New York/Stony Brook (United States)
Donald Harrington, State Univ. of New York/Stony Brook (United States)


Published in SPIE Proceedings Vol. 5746:
Medical Imaging 2005: Physiology, Function, and Structure from Medical Images
Amir A. Amini; Armando Manduca, Editor(s)

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