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Proceedings Paper

Semiconductor nanocrystal-aptamer bioconjugate probes for specific prostate carcinoma cell targeting
Author(s): Felice Shieh; Laura Lavery; Chitai Ted Chu; Rebecca Richards-Kortum; Andrew D. Ellington; Brian A. Korgel
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Paper Abstract

Cancer of the prostate affects approximately 1 in 11 men. Current early screening for prostate cancer utilizes digital rectal examinations to detect anomalies in the prostate gland and blood test screenings for upregulated levels of prostate specific antigen (PSA). Many of these tests are invasive and can often be inconclusive as PSA levels may be heightened due to benign factors. Prostate specific membrane antigen (PSMA), a well-characterized integral membrane protein, is expressed in virtually all prostate cancers and often correlates with cancer aggressiveness. Therefore, it may be used as an indicator of cancer growth and metastases. PSMA-specific antibodies have been identified and conjugated to fluorescent markers for cancer cell targeting; however, both the antibodies and markers possess significant limitations in their pharmaceutical and diagnostic value. Here we report the use of semiconductor nanocrystals bioconjugated to PSMA-specific aptamer recognition molecules for prostate carcinoma cell targeting. The nanocrystal/aptamer bioconjugates are small biocompatible probes with the potential for color-tunability for multicolor imaging. Ongoing in vitro and in vivo research seeks to introduce these nanoparticle bioconjugates into medical diagnostics.

Paper Details

Date Published: 28 April 2005
PDF: 7 pages
Proc. SPIE 5705, Nanobiophotonics and Biomedical Applications II, (28 April 2005); doi: 10.1117/12.597249
Show Author Affiliations
Felice Shieh, Univ. of Texas at Austin (United States)
Laura Lavery, Univ. of Texas at Austin (United States)
Chitai Ted Chu, Univ. of Texas at Austin (United States)
Rebecca Richards-Kortum, Univ. of Texas at Austin (United States)
Andrew D. Ellington, Univ. of Texas at Austin (United States)
Brian A. Korgel, Univ. of Texas at Austin (United States)

Published in SPIE Proceedings Vol. 5705:
Nanobiophotonics and Biomedical Applications II
Alexander N. Cartwright; Marek Osinski, Editor(s)

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