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Proceedings Paper

Quantitative photoacoustic imaging: fitting a model of light transport to the initial pressure distribution
Author(s): B. T. Cox; S. R. Arridge; K. P. Kostli; P. C. Beard
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Paper Abstract

Photoacoustic imaging, which generates a map of the initial acoustic pressure distribution generated by a short laser pulse, has been demonstrated by several authors. Quantitative photoacoustic imaging takes this one stage further to produce a map of the distribution of an optical property of the tissue, in this case absorption, which can then be related to a physiological parameter. In this technique, the initial pressure distribution is assumed to be proportional to the absorbed laser energy density. A model of light transport in scattering media is then used to estimate the distribution of optical properties that would result in such a pattern of absorbed energy. The light model used a finite element implementation of the diffusion equation (with the delta-E(3) approximation included to improve the accuracy at short distances inside the scattering medium). An algorithm which applies this model iteratively and converges on a quantitative estimate of the optical absorption distribution is described. 2D examples using simulated data (initial pressure maps) with and without noise are shown to converge quickly and accurately.

Paper Details

Date Published: 25 April 2005
PDF: 7 pages
Proc. SPIE 5697, Photons Plus Ultrasound: Imaging and Sensing 2005: The Sixth Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics, (25 April 2005); doi: 10.1117/12.597190
Show Author Affiliations
B. T. Cox, Univ. College London (United Kingdom)
S. R. Arridge, Univ. College London (United Kingdom)
K. P. Kostli, Univ. College London (United Kingdom)
P. C. Beard, Univ. College London (United Kingdom)


Published in SPIE Proceedings Vol. 5697:
Photons Plus Ultrasound: Imaging and Sensing 2005: The Sixth Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics
Alexander A. Oraevsky; Lihong V. Wang, Editor(s)

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