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Proceedings Paper

Fluoroscopic-guided radiofrequency ablation of the basivertebral nerve: application and analysis with multiple imaging modalities in an ovine model (Invited Paper)
Author(s): Jeffrey A. Bergeron; Cliff J. Eskey; Mohammed Attawia; Samit J. Patel; Thomas P. Ryan; Richard Pellegrino; Jeffrey Sutton; John Crombie; B. T. Paul; P. Jack Hoopes
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Paper Abstract

Pathologic involvement of the basivertebral nerve, an intraosseous vertebral nerve found in humans and most mammalian species, may play a role in some forms of back pain. This study was designed to assess the feasibility and effects of the percutaneous delivery of radiofrequency (RF) energy to thermally ablate the basivertebral nerve in the lumbar vertebrae of mature sheep. Using fluoroscopic guidance, a RF bipolar device was placed and a thermal dose delivered to lumbar vertebral bodies in sheep. Post-treatment assessment included multiple magnetic resonance imaging (MRI) techniques and computed tomography (CT). These data were analyzed and correlated to histopathology and morphometry findings to describe the cellular and boney structural changes resulting from the treatment. Imaging modalities MRI and CT can be implemented to non-invasively describe treatment region and volume, marrow cellular effects, and bone density alterations immediately following RF treatment and during convalescence. Such imaging can be utilized to assess treatment effects and refine the thermal dose to vertebral body volume ratio used in treatment planning. This information will be used to improve the therapeutic ratio and develop a treatment protocol for human applications.

Paper Details

Date Published: 14 April 2005
PDF: 12 pages
Proc. SPIE 5698, Thermal Treatment of Tissue: Energy Delivery and Assessment III, (14 April 2005); doi: 10.1117/12.596654
Show Author Affiliations
Jeffrey A. Bergeron, Dartmouth Medical School and Dartmouth Hitchcock Medical Ctr. (United States)
Cliff J. Eskey, Dartmouth Medical School and Dartmouth Hitchcock Medical Ctr. (United States)
Mohammed Attawia, Depuy Spine (United States)
Samit J. Patel, Ethicon, Inc. (United States)
Thomas P. Ryan, Ethicon, Inc. (United States)
Richard Pellegrino, Depuy Spine (United States)
Jeffrey Sutton, Depuy Spine (United States)
John Crombie, Ethicon, Inc. (United States)
B. T. Paul, Dartmouth Medical School and Dartmouth Hitchcock Medical Ctr. (United States)
P. Jack Hoopes, Dartmouth Medical School and Dartmouth Hitchcock Medical Ctr. (United States)


Published in SPIE Proceedings Vol. 5698:
Thermal Treatment of Tissue: Energy Delivery and Assessment III
Thomas P. Ryan, Editor(s)

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