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Proceedings Paper

A method to improve the reproducibility of in vivo reflectance spectroscopy
Author(s): Alexandre Douplik; David Shalaby; Brian C. Wilson; Joseph Perry
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Paper Abstract

The goal of this study was to optimize measurement techniques for tissue point spectroscopy during gastrointestinal (GI) endoscopy, as part of a program to enhance and apply autofluorescence/reflectance imaging for early GI cancer detection. The effect of fiberoptic probe pressure on tissue on the measured diffuse reflectance spectra was evaluated, with both fiber-to-fiber probe geometry (standard contact probe) and imaging illumination geometry (wide field illumination and fiber collection) for the wavelength range 440-640 nm, using normal skin in vivo as a model tissue, and by taking continuous spectral measurements while the fiber is approaching the tissue. The most significant finding was a sudden change in the reflectance signal that occurs as the probe comes into contact with the tissue surface.

Paper Details

Date Published: 15 April 2005
PDF: 5 pages
Proc. SPIE 5695, Optical Interactions with Tissue and Cells XVI, (15 April 2005); doi: 10.1117/12.596427
Show Author Affiliations
Alexandre Douplik, Xillix Ltd. (Canada)
David Shalaby, Ontario Cancer Institute/Univ. of Toronto (Canada)
Brian C. Wilson, Ontario Cancer Institute/Univ. of Toronto (Canada)
Joseph Perry, Ontario Cancer Institute/Univ. of Toronto (Canada)

Published in SPIE Proceedings Vol. 5695:
Optical Interactions with Tissue and Cells XVI
Steven L. Jacques; William P. Roach, Editor(s)

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