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Proceedings Paper

Volumetric analysis of tumors in rodents using the variable resolution x-ray (VRX) CT-scanner
Author(s): M. Waleed Gaber; Christy M. Wilson; Christopher D. Duntsch; Hemant Shukla; Janice A. Zawaski; Lawrence M. Jordan; David A. Rendon; Sravanthi Vangalaa; Gary S. Keyes; Frank A. DiBianca
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Paper Abstract

The Variable Resolution X-ray (VRX) CT system, developed at the UTHSC, Memphis, has the potential for use in animal imaging. Animal models of tumor progression and pharmacological impact are becoming increasingly important in understanding the molecular and mechanistic basis of tumor development. In general, CT-imaging offers several advantages in animal research: a fast throughput of seconds to minutes reducing the physiological stress animals are exposed to, and it is an inexpensive modality affordable to many animal laboratories. We are developing the VRX CT scanner as a non-invasive imaging modality to measure tumor volume, progression, and metastasis. From the axial images taken by the VRX CT-scanner, tumor area was measured and the tumor volume was calculated. Animals were also imaged using an optical liquid nitrogen-cooled CCD camera to detect tumor fluorescence. A simple image fusion with a planner x-ray image was used to ascertain the position of the tumors, animals were then sacrificed the tumors excised, and the tumor volume calculated by physical measurements. Furthermore, using a specially designed phantom with three spheres of different volumes, we demonstrated that our system allowed us to estimate the volume with up to 10% accuracy; we expect this to increase dramatically in the next few months.

Paper Details

Date Published: 14 April 2005
PDF: 7 pages
Proc. SPIE 5746, Medical Imaging 2005: Physiology, Function, and Structure from Medical Images, (14 April 2005); doi: 10.1117/12.595786
Show Author Affiliations
M. Waleed Gaber, Univ. of Tennessee Health Science Ctr. /Memphis (United States)
Christy M. Wilson, Univ. of Tennessee Health Science Ctr. /Memphis (United States)
Christopher D. Duntsch, Univ. of Tennessee Health Science Ctr. /Memphis (United States)
Hemant Shukla, Univ. of Tennessee Health Science Ctr. /Memphis (United States)
Janice A. Zawaski, Univ. of Tennessee Health Science Ctr. /Memphis (United States)
Lawrence M. Jordan, Univ. of Tennessee Health Science Ctr. /Memphis (United States)
David A. Rendon, Univ. of Tennessee Health Science Ctr. /Memphis (United States)
Sravanthi Vangalaa, Univ. of Tennessee Health Science Ctr. /Memphis (United States)
Gary S. Keyes, Univ. of Tennessee Health Science Ctr. /Memphis (United States)
Frank A. DiBianca, Univ. of Tennessee Health Science Ctr. /Memphis (United States)


Published in SPIE Proceedings Vol. 5746:
Medical Imaging 2005: Physiology, Function, and Structure from Medical Images
Amir A. Amini; Armando Manduca, Editor(s)

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